音頻科普:幫助免疫係統對抗癌症獲諾貝爾獎
James P. Allison and Tasuku Honjo share the Nobel Prize for their work on harnessing the cancer patient's own immune system to destroy tumors.James P. Allison和Tasuku Honjo因他們在利用癌症患者自身的免疫係統來摧毀腫瘤方麵的工作分享了諾貝爾獎。
撰文\播音:史蒂夫·米爾斯基(Steve Mirsky)
翻譯:邱燕寧
審校:張清越
“The Nobel Assembly at Karolinska Institute has today decided to award the 2018 Nobel Prize in Physiology or Medicine, jointly to and Tasuku Honjo for their discovery of .”
“今天,卡羅林斯卡學院的諾貝爾大會決定將2018年諾貝爾生理學或醫學獎授予James P. Allison和Tasuku Honjo,以表彰他們發現了通過抑製負向免疫調節來治療癌症的方法。”
Thomas Perlmann, secretary of the Nobel Assembly shortly after 5:30 this morning Eastern time.
美國東部時間今天上午5:30分後不久,諾貝爾大會秘書Thomas Perlmann如是說。
“James P. Allison was born in Alice, in Texas, in the United States. He performed his prize-winning studies at the University of California, Berkeley, and at Memorial Sloan Kettering Cancer Center in New York. He is now active at The University of Texas M. D. Anderson Cancer Center in Houston. Tasuku Honjo was born in Kyoto, in Japan. He performed his prize-winning studies at Kyoto University, where he is still active.”
James P. Allison在美國德克薩斯州的Alice出生。他在加州大學伯克利分校和紐約紀念斯隆凱特琳癌症中心進行了獲獎研究。他現在就職於休斯頓的德克薩斯大學安德森癌症中心。本卓生於日本京都。他在京都大學完成了他的獲獎研究,現在仍在那裏工作。
Karolinska Institute immunologist Klas Kärre, a member of the Nobel Committee, explained the significance of the work of the new Nobel laureates:
卡羅林斯卡研究所免疫學家Klas Kärre是諾貝爾委員會的成員,他解釋了新諾貝爾獎獲得者的工作意義:
“Allison’s and Honjo’s discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike the previous strategies it is not based on targeting the cancer cells, but rather the brakes, the checkpoints, of the host immune system. The seminal discoveries by the two laureates constitute a paradigmatic shift and a landmark in the fight against cancer.”
Allison和Honjo的發現為癌症治療增加了新的基石。它與之前的策略不同,代表了一個全新的理念,因為它不是針對癌細胞,而是針對宿主免疫係統的檢查點。兩位獲獎者的開創性發現構成了一個範式轉變,也是抗擊癌症的一個裏程碑。
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